Saint Pius V, after the Battle of Lepanto, decided to establish the feast of the Holy Rosary, and that the invocation "Mary Help of Christians" should also be included in the Lauretan Litany;

Pope Pius VII instituted the feast of Mary Help of Christians, in memory of his return to Rome after being imprisoned in the palace of Fontainebleau by Napoleon Bonaparte;

Pope John XXIII cultivated a special devotion to the Help of Christians and proclaimed her Patroness of the Council with the titles of Auxilium Christianorume Auxilium Episcoporum;

The first stone was laid on 27 April 1865, in the presence of Prince Amedeo di Savoia;
On September 23, 1866 the great dome was finished;
In 1867 the statue of the Madonna was placed at the end of the dome;

- The first Christians in Greece, Egypt, Antioch, Ephesus, Alexandria and Athens called the Blessed Virgin Mary with the name of "Help of Christians";

- Mary Help of Christians interceded in the battles of Lepanto and Vienna;